Author: Hannsjörg Schröder Publisher: Springer Nature ISBN: 3030198987 Category : Medical Languages : en Pages : 350
Book Description
This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.
Author: Charles Watson Publisher: Academic Press ISBN: 0123694973 Category : Medical Languages : en Pages : 795
Book Description
The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlasesA detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness
Author: Division of Neurophysiology Tim Bliss Publisher: Oxford University Press ISBN: 9780195100273 Category : Medical Languages : en Pages : 832
Book Description
The hippocampus is one of a group of remarkable structures embedded within the brains medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. This volume offers an account of what the hippocampus does, and what happens when things go wrong.--[Source inconnue].
Author: Josiah An Publisher: ISBN: Category : Languages : en Pages : 184
Book Description
Unilateral lesions in associative areas including medial agranular cortex (AGm), posterior parietal cortex (PPC), dorsocentral striatum (DCS), and thalamus in rats are known to result in hemispatial neglect. We hypothesized that these regions in mice may be similar to rats and might be used as a model to study hemispatial neglect. Cortico efferent projections from AGm to DCS and thalamus were first determined by placing an anterograde tracer in AGm and observing the resulting striatal and thalamic axonal terminal field labeling. Retrograde injections were made in DCS to confirm the results of anterograde tracing results and possibly determine additional projection from other areas of the brain. Axonal labeling for the anterograde study and cell body labeling for the retrograde study were examined at the areas of interest. For the anterograde study, DCS and lateral posterior thalamic nucleus were labeled intensely indicating that there is a strong projection from AGm to striatum and thalamus in mice. Labeling seen in AGm and thalamus in the retrograde study showed that DCS receives input from the cortex and thalamus as seen in rats, likely forming a cortical-striatal-thalamic network that may be important in directed attention. These findings suggest that mice likely have a similar cortico-striatal-thalamic network to that previously described as mediating directed attention in rats, and can possibly be used as a model for hemispatial neglect.
Author: George Paxinos Publisher: Academic Press ISBN: 0125476221 Category : Psychology Languages : en Pages : 353
Book Description
This atlas provides an accurate and detailed depiction of all brain structures at fetal stage E17.5, Day of birth, and Day 6 postnatal. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs. It is an indispensable guide for the interpretation of nervous system changes in gene knockout and transgenic mice. Contains: 43 photographs and drawings of Nissl-stained coronal sections of the brain of a fetal mouse at E17.5 days, 65 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse on the day of birth, and 73 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse aged 6 days postnatal. The drawings are based on the study of sections stained with Nissl and a range of neuroactive substances. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs.
Author: Kathleen S. Rockland Publisher: Frontiers Media SA ISBN: 2889199169 Category : Languages : en Pages :
Book Description
An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.
Author: Hannsjörg Schröder
Author: Charles Watson
Author: Division of Neurophysiology Tim Bliss
Author: Ludovico Silvestri
Author: Josiah An
Author: George Paxinos
Author: Kathleen S. Rockland
Author: Adam Zachary Weitemier
Author: Johathan C. Lau
Author: Weiya Mu